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Cross-Linked Hyaluornic Acid

Hyaluronic Acid Dermal Filler

Singfiller is BDDE cross-linked hyaluronic acid filler, which is reticulated and obtained via bio-fermentation technology. Singderm consists of modified hyaluronic acid (HA) produced by bacteria, formulated to a concentration of 24mg/ml and 0.3% lidocaine in a physiologic buffer. Singfiller and Singderm can be used for nasolabial folds, frown lines, wrinkles across the forehead, neck lines, nose, chin, lip, earlobe, temple and cheek. Singfiller® Meso is dermal filler consists of non cross-linked hyaluronic acid, being a sterile, biodegradable, nonpyrogenic, viscoelastic, clear, colorless, homogenized gel, this product is intended to be used for Mesotherapy.


Product Details 1. What is Singfiller R cross-linked hyaluronic gel ? Singfiller ® is a cross-linked sodium hyaluronate acid, which derived from fermentation and this product can only be used in the legally approved medical institution by qualified doctors in this field. According to different…

Product Details

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2.Hyaluronic acid

Another name for hyaluronic acid is hyaluronic acid. Hyaluronic acid is a mistranslation. RESTIAID hyaluronic acid hyal- means glass-like, bright and transparent, while uronic acid refers to uronic acid. Hyaluronic acid has nothing to do with uric acid.

3.The production process and technology of hyaluronic acid determine the difference in quality. Therefore, the product must be produced from the correct source in order to have therapeutic effects. In general, there are three methods for refining:

(1). Animal tissue: The main raw materials are cockscomb and bovine eye glass. The raw materials are degreased and dehydrated with acetone or ethanol, soaked in distilled water, filtered, and then treated with sodium chloride aqueous solution and chloroform solution, followed by trypsin to obtain a mixed solution. Finally, it is treated with ion exchanger to purify and obtain refined hyaluronic acid. The extraction rate of this method is extremely low, only about 1%, and the separation process is complicated, resulting in expensive hyaluronic acid, reaching USD 5,000/kg, which limits the Large amount of use in cosmetics.

(2). Microbial fermentation: using glucose as a carbon source fermentation liquid. Fermentation in the medium for 48 hours, after the fermentation is finished, the mycelium and impurities are removed by filtration, and then a high-purity product is obtained by simple operation such as alcohol precipitation. Fermentation is employed. The hyaluronic acid produced by the method has the advantage of being able to set the molecular weight according to the design of the product. The key to the fermentation method is the selection of strains, and the use of streptococci and lactic acid bacteria.

(3), chemical synthesis: the use of natural enzyme polymerization; first use the polysaccharide polymer to synthesize “hyaluronic acid oxyazacyclopentene derivative”, and then add water-decomposing enzyme to produce a complex of derivatives and enzymes, and finally Hyaluronic acid was synthesized by removing the enzyme from the reaction solution at 90 °C. The artificial synthesis method can greatly reduce the manufacturing cost of hyaluronic acid, but the structure is less pure.

3.    Application: 

Used for plastic surgery to remove wrinkles or Derma filling:

facial filler

lip enhancer

    cheek enhancement

body enlargement

    nose up injection

    breast filler

smile line injection

Singclean Medical is one of the leading china dermal filler manufacturers for facial filling lip enhancer, nose up, cheek filling, breast filler manufacturers and suppliers in China. With many highly qualified staff and advanced technology, we warmly welcome you to wholesale our quality medical product at competitive price which has no doubt to bring you many benefits.


4.Important Safety Information

·Singfiller® is only intended for use as an intradermal implant.

·Do not inject intravascularly. As for other injectable medical devices, inadvertent injection into blood vessels could potentially lead to vascular occlusion, ischemia and necrosis. Aspiration prior to injection is recommended.

·If blanching is observed, i.e, the overlying skin turns a whitish color, the injection should be stopped at once and the area massaged until it returns to a normal color.

·Do not use in patients with bleeding disorders or in patients who are taking thrombolytics or anticoagulants.

·Do not resterilizesingfiller

·Do not mix with other products prior to injection of the device.

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