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Singclean Medical Hyaluronic Acid Sodium Gel Production Method
April 19, 2021

Osteoarthritis (OA) is a long-term chronic disease characterized by the deterioration of cartilage in joints which results in bones rubbing together and creating stiffness, pain, and impaired movement. The disease most commonly affects the joints in the knees, hands, feet, and spine and is relatively common in shoulder and hip joints1.
Osteoarthritis (OA) is estimated to affect 630 million people worldwide – 15% of all the people on the globe2.
Over the last decades, there is an ongoing trend to use Intra-articular injections of either corticosteroids, analgesics/anti-inflammatory drugs, polymerized collagen, anti-cytokine drugs, or hyaluronic acid as alternative modalities to maximize the topical effect and minimize the systemic adverse effects. Each injection has been shown to lower the pain in patients in some form, though hyaluronic acid treatments seem to be the safest and last the longest3.
When a patient is no longer able to control osteoarthritis pain with ibuprofen or other nonsteroidal anti-inflammatory drugs (NSAIDs), or the patient can’t tolerate these drugs (which can cause side effects such as stomach bleeding and kidney problems), hyaluronic acid injections are one treatment option doctors may offer.
About Hyaluronate Acid Injection
Hyaluronate acid is the major chemical component of synovial fluid, secreted by synovial cells, fibroblasts and chondrocytes, acts as a lubricant and shock absorber which plays its essential role for protecting the articular cartilage.“However, there’s more to it than that,” says Case Western Reserve University rheumatologist Roland W. Moskowitz, MD.. "Hyaluronic acid has a lot of other activities in the joint.”For example, research suggests that hyaluronic acid interfere with prostaglandins and cytokines, naturally occurring compounds that promote inflammation.
The idea of using hyaluronic acid to treat osteoarthritis was originally proposed around 73 years ago by Hungarian scientist Endre A. Balasz. Hyaluronic acid injections (also known as viscosupplements) are approved by the U.S. Food and Drug Administration (FDA) for treating osteoarthritis of the knee, though some doctors have used the therapy on other joints, such as the hip and ankle4.
About SingJoint
SingJoint® is a kind of colorless transparent liquid gel which is made of hyaluronic acid, from streptococcal fermantation metabolites. SingJoint® is used to relieve knee pain due to osteoarthritis(OA). It is for patients who do not get enough relief from simple painkillers such as acetaminophen, or from exercise and physical therapy.
•Safety (Endogenous, fermentation )
•No immunogen (no species differences, no autoimmune rejection)
•Biodegradable (In vivo degradation products are water, carbon dioxide, monosaccharides and so on toxic free and safe)
•High Molecular Weight (1100-2100Kdal.)
•Hangzhou Singclean specialized in the manufacture of this product for 15 years.
•The quality is Satisfied by customers all over the world.
•The price is competitive compared with European brands.
•OEM available.
①Low concentration:
10mg/ml and 12mg/ml
3 to 5 injections, given one week apart
provides up to 6 months of osteoarthritis pain relief.
②High concentration:
one-injection treatment
Provides up to six months of osteoarthritis pain relief
1 World Health Organization https://www.who.int/medicines/areas/priority_medicines/Ch6_12Osteo.pdf
2 Hospital for Special Surgery https://www.hss.edu/osteoarthritis-research.asp
3 Recent advances in hyaluronic acid based therapy for osteoarthritis by Steven Bowman,Mohamed E. Awad, Mark W. Hamrick, Monte Hunter, and Sadanand Fulzele
4 Hyaluronic Acid Injections for Osteoarthritis by Timothy Gower

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